Once in a while Toolbox must be uninstalled prior to upgrading to a newer version of AutoCad.  (Because your existing version of Toolbox doesn't recognize or support the newer version of AutoCad.)

There's a knowledge base article that discusses this operation, but it doesn't really answer the million dollar question.  (Other than telling you to perform a backup)

Do your configurations remain intact when you uninstall Toolbox Standard or do you have to recreate them?  (e.g. Export first and then Import after the upgrade)

Here's the article: